Tumor Stroma Interactions
The Tumor Stroma Interactions group studies the mechanisms leading to leukemia progression.
Activities
The Tumor Stroma Interactions research group is a dynamic and multinational team studying the mechanisms leading to leukemia progression with the goal to identify new prognostic markers and therapeutic targets.
Some of the group’s research projects include:
- Exosomes in B-cell malignancies – to identify potential biomarkers in exosomes derived from murine preclinical models and cells of patients affected by hematologic malignancies and to test their influence on cells from the microenvironment.
- Tumor immunology – to identify new cellular populations which could be used as biomarkers for the response to treatment and potential new therapeutic targets.
- New therapeutic targets in CLL – to investigate the therapeutic efficacy and mode of action of new molecules inhibiting translation machinery and prohibitins in chronic lymphocytic leukemia (CLL), both in patient cells and in a murine model.
Collaborations
Projects & clinical trials
Featured team members
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Titiksha
Basu Postdoctoral Fellow -
Coralie
Borne Postdoctoral Fellow -
Chloé
Duculty PhD Student -
Maxmilan
Jeyakumar Postdoctoral Fellow -
Vanessa
Klapp PhD Student -
Anne
Largeot Scientist -
Etienne
Moussay Group Leader -
Jérôme
Paggetti Group Leader
Scientific publications
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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle – 28/02/2024
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Minimal information for studies of extracellular vesicles (MISEV2023) – 01/02/2024
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Power out chronic lymphocytic leukemia – 03/08/2023
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Role of AHR and HIF1α transcription factors in normal and chronic lymphocytic leukemia B lymphocytes – 21/12/2023
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Targeting mRNA translation aberrations – 01/01/2023
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Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia – 03/11/2023
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Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia – 22/06/2023
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Immunologically relevant effects of radiation therapy on the tumor microenvironment – 18/05/2023
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Formate promotes invasion and metastasis in reliance on lipid metabolism – 30/08/2023
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Molecular determinants of immunogenic cell death elicited by radiation therapy – 01/01/2023
Related News
Job vacancies
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Internship Position in Leukemia Research (Master students) – AL0124 (JF/INT0124/AL/TSI)
Department of Cancer Research – Tumor Stroma Interactions
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Post-Doctoral Fellow in Cancer Research (MC/PDCR1123/EM/TSI)
Department of Cancer Research – Tumor Stroma Interactions